Abstract T cell discrimination of self and non-self is the foundation of the adaptive immune response, and is orchestrated by the interaction between T cell receptors (TCRs) and their cognate ligands presented by major histocompatibility (MHC) molecules.However, the impact of host immunogenetic variation on the diversity of the TCR repertoire remains unclear.Here, we analyzed a cohort of 666 individuals Wellington Socks with TCR repertoire sequencing.We show that TCR repertoire diversity is positively USB Adapter Cable associated with polymorphism at the human leukocyte antigen class I (HLA-I) loci, and diminishes with age and cytomegalovirus (CMV) infection.
Moreover, our analysis revealed that HLA-I polymorphism and age independently shape the repertoire in healthy individuals.Our data elucidate key determinants of human TCR repertoire diversity, and suggest a mechanism underlying the evolutionary fitness advantage of HLA-I heterozygosity.